特殊ペプチド (カタログ品)

トランスポーターペプチド | コスメティックペプチド | ファージディスプレイ | お問い合わせ・ご注文

Peptide cargo – Transporter peptide

目的分子を真核細胞内に搬送するトランススポートペプチドはペプチドカーゴとも呼びます。

商品リストはこちら。

Cambridge Research Biochemicals(CRB)は、医学研究や製薬業界のための研究用試薬(主にペプチドおよび抗体)のカスタム供給に特化したイギリスの会社であり、ペプチド-カーゴ(カーゴ:膜輸送で運ばれるタンパク質)を組み合わせた大規模な並列構築治療薬についての新規で特許性のある方法のライセンスを取得しました。同社は、新たな治療薬の提供と開発の一助となるペプチド-カーゴ複合体のカスタムメイドのライブラリーを研究者や製薬会社に提供するために、10月にサービスを開始しました。
この方法は、MRC分子生物学研究所(MRC-LMB)の科学者が細胞にカーゴ治療薬を運ぶことができる細胞透過性ペプチドの開発に取り組むことから始まりました。このようなペプチド運搬治療による効果を得ることができる病気の種類は、筋ジストロフィー、癌および代謝性疾患など広範囲に渡ります。こうした治療薬を開発するためには、治療のための薬剤カーゴの運搬に最適なペプチドを決定するために、ペプチド-カーゴの組み合わせの様々なテストが必要です。この新技術は、初期段階の薬物スクリーニングプロセスをより迅速にでき、化学の専門知識無しで、潜在的新規治療薬の運搬および開発に向けたペプチド-薬物複合体の大規模数な準備および試験を迅速にすることができます。

CRBのコマーシャルディレクターであるEmily Humphrysは、次のようにコメントをしています。「私たちは、学術研究者と産業界の双方に、薬剤運搬において最も適切な細胞透過性ペプチドを選択できる、待望のサービスを提供できることを本当に嬉しく思います。企業として、CRBは、広範なペプチド化学に関する能力を持ち、MRC-LMB とは1980年の会社設立から長年良好な関係を持っており、2010年からはペプチドおよび抗体の継続的な供給契約を結んでいます。このように協力しあえることは栄誉なことです。」

MRCの科学者であるMike Gait博士は、次のようにコメントをしています。「CRBは、私たちの新しい方法を取り入れており、最終的に新しい治療法の開発を可能としてくれる多くの研究者および産業にそれらが開かれることを非常に嬉しく思います。」

この方法は、MRCの技術をもってCRBがライセンスを得ました。MRCの技術は、技術譲渡サービスとして提供しています。

Dr Mike Gait Group Leader, MRC-LMB) & Emily Humphrys (Commercial Director, CRB)

Transporter Peptides™ 商品リスト


細胞生物学研究で主な困難の一つに真核細胞の膜を透過する検査分子の効果的な搬送があります。この限界を克服するためにCRBはトランスポーターペプチドとよばれる新たな領域の製品を紹介しました。それらは論文裏付けのある細胞透過性ペプチド (CPPs)、ペプチドをCargo (カーゴ)にカップリングするのを容易化するCys(Npys)を予備反応でつけたものです。

Product No. Peptide Qty (mg) 参考価格
SP-15-0030-01 H-Cys(Npys)-Penetratin 43-58 1 64,000
-05 5 128,000
SP-15-0031-01 H-Cys(Npys)-TAT 48-60 1 64,000
-05 5 128,000
SP-15-0032-01 H-Cys(Npys)-pVEC 615-632 1 64,000
-05 5 128,000
SP-15-0033-01 H-Cys(Npys)-Transportan 10 1 64,000
-05 5 128,000
SP-15-0034-01 H-Cys(Npys)-S413-PV 1 64,000
-05 5 128,000
SP-15-0035-01 H-Cys(Npys)-(Arg-Ahx-Arg)4-NH2 1 64,000
-05 5 128,000
CPP Kit Kit containing 1mg of each peptide 1 kit 128,000

Cosmetic Peptide

ペプチドを化粧品業界で …..

高品質なペプチドをご提供いたします。
今、世界中の化粧品業界でペプチドが注目され、実際に使われ始めています。

化粧品ペプチドはある種の生物機能を抑制する能力を含めたマルチ機能によって、美の革命をリードしつつあります。
ほとんどの繁栄しているスキンケア関係の会社がブームというべきこの分野の研究に参加しているように、かつてないほど、より高い品質を得るための化粧品ペプチドカスタム合成のニーズがあります。
このニーズに応えるべく、研究向けシングルペプチドのグラム合成と化粧品ペプチドのGMPグレードの合成というニーズに正確に対応できる施設と能力を備えています。

製品について

  • 量: mg – Kg まで (GMP and non-GMP grade)
  • 純度: Crude to >98%.
  • 修飾: さまざまの要請にお答えします。お客様の正しい選択にお力添えもできます。

ご使用例

Product No. Name Cosmetic Brands Containing Peptide Suggested Usages
C014-10926-01 Acetyl Hexapeptide-3
  • Replexion: Anti Aging Skin Care Cream
  • Pretox20: Wrinkle Cream
  • Relax-A-LineTM Topical Serum: For shallower lines. Acetyl Hexapeptide 3 relaxes facial muscles that cause dynamic wrinkles
Relaxes facial tension, leading to the reduction of facial lines and wrinkles. It is a safe, effective, more affordable alternative to Botox
C014-10928-01 Palmitoyl Hexapeptide
  • Ageless: Rejuvenate anti-aging serum
  • Granactivea?¢ Hexapeptide
  • Skin Fusion: A mineral foundation and powder
Stimulates fibroblasts proliferation, Imparts firming effect, smoothes out wrinkles while strengthening the skin’s natural barrier function
C014-10929-01 Palmitoyl Tetrapeptide-3
  • Avon: Anew Alternative Intensive Age Treatment
  • SuperMax: Multi-Peptide Skin Solution Serum
  • Osmotics: Blue Copper 5 Face Lifting Serum, Eye Surgery Under Eye Rejuvenator
It delays the effects of premature aging by improving the elasticity and firmness of the skin. It hydrates, protects and smoothes skin.
C014-10927-01 Palmitoyl Pentapeptide
  • G.M. COLLIN: Retinol Advanced + Matrixyl + Q10
  • Aziz Luminous Peptide Serum
  • Skinmedic: Multi Peptide Anti ageing Serum
  • Replexion: Anti Aging Skin Care Cream
  • Newspirit: Pentapeptide-SFa?¢ Eye Contour Serum
  • Nutra-Luxe: Kaviar Night Serum Firmer Skin
  • Actively stimulates the production of collagen I and IV, fibronectin and glycosaminoglycans in the dermis. Assists in increasing skin thickness through these actions.
  • Aids in tissue regeneration and skin healing
  • Acts to enhance dermal and epidermal hydration
  • Increases the effects of resurfacers, peels and laser treatments
C014-10930-01 PAL-GHK
  • Lip’s CRA?ME: Masque pour les lA¨vres
  • Modele: Advanced Lip Restoring Treatment
  • Urban Nutrition: Bellaplexa?¢
Re-structuring the connective tissue by stimulating the production of collagen and of the glycosaminoglycans acts as a natural sun protector, firms skin and helps with

ペプチド詳細

  1. Acetyl Hexapeptide-3 Argireline Peptide
    Sequence (1LC): Ac-EEMQRR-CONH2
    Sequence (3LC): Ac-Glu-Glu-Met-Gln-Arg-Arg-CONH2
    Catalog : 10926-01
    Unit: 1 mg
    Price/Unit:
    Purity: > 95% by HPLC
    Format: Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
    Description: Acetyl hexapeptide-3, otherwise known as argireline is a synthetic anti-aging cosmetic peptide derived from natural proteins.1 Its mechanism of action is competing with SNAP-25 to SNARE complex. This peptide has been attributed to decreasing wrinkle formation by binding to the SNARE-receptor thus blocking the production of neurotransmitter which then reduces facial muscle contraction.2 It has been used as a replacement for botox. Formulations with 10% concentration acetyl hexapeptide 3 have been shown to reduce the depth of wrinkles up to 30% after 30 days of trial use.3
    Storage: -20
    Product Usage: This product is for research use only. Not for use in diagnostic or therapeutic procedures.
  2. Palmitoyl hexapeptide
    One-Letter Sequence: pal-VGVAPG
    Three-Letter Sequence: Pal-Val-Gly-Val-Ala-Pro-Gly-OH
    Catalog#: 10928-01
    Purity: > 95% by HPLC
    Solubility: Distilled water for a solution up to 2 mg/ml, otherwise we recommend using DMSO
    Format: Each vial contains lyophilized solid packaged and supplied as a trifluoroacetate salt
    Price/Unit: 37,000円
    Unit: 1 mg
    M.W.: 737.08
    Long-Term Storage: -20
    Product Usage: For laboratory research use only, not for diagnostic use! Not for use in humans.
  3. Palmitoyl Tetrapeptide-3
    One-Letter Sequence: pal-GQPR
    Three-Letter Sequence: Pal-Gly-Gln-Pro-Arg-OH
    Catalog#: 10929-01
    Purity: > 95% by HPLC
    Solubility: Distilled water for a solution up to 2 mg/ml, otherwise we recommend using DMSO
    Format: Each vial contains lyophilized solid packaged and supplied as a trifluoroacetate salt
    Price/Unit: 31,000円
    Unit: 1 mg
    M.W.: 694.55
    Long-Term Storage: -20
    Product Usage: For laboratory research use only, not for diagnostic use! Not for use in humans.
  4. Palmitoyl Pentapeptide
    One-Letter Sequence: pal-KTTKS
    Three-Letter Sequence: Pal-Lys-Thr-Thr-Lys-Ser-OH
    Catalog#: 10927-01
    Purity: > 95% by HPLC
    Solubility: Distilled water for a solution up to 2 mg/ml, otherwise we recommend using DMSO
    Format: Each vial contains lyophilized solid packaged and supplied as a trifluoroacetate salt
    Price/Unit: 37,000円
    Unit: 1 mg
    M.W.: 802.05
    Long-Term Storage: -20
    Product Usage: For laboratory research use only, not for diagnostic use! Not for use in humans.
    Reference/Citations: Int J Cosmet Sci, Volume 27 Issue 3 Page 155; Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin1. L. R. Robinson,; N. C. Fitzgerald,; D. G. Doughty,; N. C. Dawes
  5. Palmitoyl-oligopeptide, PAL-GHK
    Sequence (1LC): pal-GHK
    Sequence (3LC): Pal-Gly-His-Lys-OH
    Catalog : 10930-01
    Unit: 1 mg
    Price/Unit:
    Purity: > 95% by HPLC
    Format: Each vial contains lyophilized solid packaged and supplied as a trifluoroacetate salt
    Storage: -20
    Product Usage: This product is for research use only. Not for use in diagnostic or therapeutic procedures.

ファージディスプレイ ペプチドライブラリー

Besides using the publically available peptide libraries, Creative Biolabs also provide various peptide libraries that were constructed in house:

We carry two good linear peptide libraries: one is 16-mer and the other is 20-mer. They are based on the same true phage system as NEB Ph.D. peptide libraries. In theory, there are about 3-5 copies of peptide on each phage virion.

TriCo-16™ Phage Display Peptide Library

  1. Type: pIII-fusion, True Phage Display
  2. Format: 16-mer peptide library
  3. Capacity: 2.60×1010
  4. Trimer codons technology
  5. Avoid stop and non-sense codon
  6. Trimer codon for cysteine was excluded

TriCo-20™ Phage Display Peptide Library

  1. Type: pIII-fusion, True Phage Display
  2. Format: 20-mer peptide library
  3. Capacity: 1.70×109
  4. Trimer codons technology
  5. Avoid stop and non-sense codon
  6. Trimer codon for cysteine was excluded

 

As validated by quality control DNA sequencing, more than 97% of randomly picked clones from these two libraries contained dsDNA inserts, and only an insignificant percentage of them harbored longer or shorter diversified peptides. None stop codons were founded as expected. Also, there was no single nucleotide deletion or insertion detected; importantly, non-sense frame-shift mutation was completely absent, demonstrating the beauty of trimer-codon strategy. Moreover, no Cys encoding codon was identified in the peptide library as designed. These Random Peptide Libraries are the best random 16-mer and 20-mer peptide libraries in terms of their quality and diversity.

Creative Biolabs also provide the following specific peptide libraries:

F88-4 Library
1. Type: pVIII-fusion (~150 copies)
2. Format: 15-mer peptide library
3. Capacity: 2.0×109
F88-Cys1 Library
1. Type: pVIII-fusion (~150 copies)
2. Format: 10-mer peptide library
3. Capacity: 5.6×108
F88-Cys2 Library
1. Type: pVIII-fusion (~150 copies)
2. Format: 11-mer peptide library
3. Capacity: 2.8×109
F88-Cys3 Library
1. Type: pVIII-fusion (~150 copies)
2. Format: 12-mer peptide library
3. Capacity: 5.5×107
F88-Cys4 Library
1. Type: pVIII-fusion (~150 copies)
2. Format: 12-mer peptide library
3. Capacity: 5.5×107
F88-Cys5 Library
1. Type: pVIII-fusion (~150 copies)
2. Format: 12-mer peptide library
3. Capacity: 5.9×108
F88-Cys6 Library
1. Type: pVIII-fusion (~150 copies)
2. Format: 14-mer peptide library
3. Capacity: 2.7×108
FUSE5-6 Library
1. Type: pIII-fusion
2. Format: 6-mer peptide library
3. Capacity: 2.0×108
FUSE5-15 Library
1. Type: pIII-fusion
2. Format: 15-mer peptide library
3. Capacity: 2.5×108
Monobody-1 Library
1. Type: pIII-fusion, Monobody
2. Capacity: 2.20×1010
3. Phage Display
4. Trimer codons technology
Monobody-2 Library
1. Type: pIII-fusion, Monobody
2. Capacity: 2.80×1010
3. Phage Display
Peptide-10™ Library
1. Type: pIII-fusion, Phagemid Phage Display
2. Format: 10-mer peptide library
3. Capacity: 1.2×109
4. NNK method
Protease-10A Library
1. Format: HiAffi tagged 10-mer peptide library
2. Capacity: 1.1×1010
3. Phage Display
4. C-terminal is labelled by protein A for purification
Protein A Domain Library
1. Type: pIII-fusion, Protein A [C Domain]
2. Capacity: 1.60×1010
3. Phage Display
Protein G Domain Library
1. Type: pIII-fusion, Protein G [C Domain]
2. Capacity: 2.40×1010
3. Phage Display
TriCo-9 Library
1. Type: pIII-fusion, Phagemid Phage Display
2. Format: 9-mer peptide library
3. Capacity: 8.60×1010
TriCo-C9 Library
1. Type: pIII-fusion, Phagemid Phage Display
2. Format: Cyclic 9-mer peptide library
3. Capacity: 8.60×1010
Vrisko Peptide Library
1. Type: pVIII-fusion
2. Format: 8-20-mer peptide library
3. Capacity: 5.0×109
4. Includes both linear (X8) and disulfide-constrained peptides
5. Provides pre-organized potential binding motifs
6. Composed of 15 different scaffolds
(including X4CX2GPX4CX4, X5CX8CX5, X5CX9CX4 and X4CX9CX5)
7. Features different arrangements of conformation biasing disulfides and randomized residues

価格はお問い合わせください。都度お見積もりいたします。

Libraries Type Length Library Size Price
Peptide-10TM pIII-fusion 10-mer peptide library 1.0×109
F88-4 pIII-fusion 15-mer peptide library 2.0×109
F88-Cys1 pVIII-fusion (~150 copies) 10-mer peptide library 5.6×108
F88-Cys2 pVIII-fusion (~150 copies) 11-mer peptide library 2.8×109
F88-Cys3 pVIII-fusion (~150 copies) 12-mer peptide library 5.5×107
F88-Cys4 pVIII-fusion (~150 copies) 12-mer peptide library 5.5×107
F88-Cys5 pVIII-fusion (~150 copies) 12-mer peptide library 5.9×108
F88-Cys6 pVIII-fusion (~150 copies) 14-mer peptide library 2.7×108
FUSE5-6 pIII-fusion 6-mer peptide library 2.0×108
FUSE5-15 pIII-fusion 15-mer peptide library 2.5×108

お問い合わせ・ご注文

こちらから。