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二重特異性抗体概要
高度な技術と長年の経験に基づいた抗体の専門メーカーであるCreative Biolabs社は様々な研究用途に適用することができる二重特異性抗体を供給することができます。
二重特異性 (モノクローナル)抗体 (BsMAb、BsAb)は、2つの異なるモノクローナル抗体の断片から構成され、結果的に2つの異なる型の抗原に結合する人工タンパク質ですが、その二重特異性抗体は、現在、がん免疫療法における有効な治療剤として役立っております。タンデムダイアボディー、DART (Dual Affinity Re-Targeting)、BiTes (bispecific T-cell engager)などの一本鎖可変フラグメント (scFv)由来のフォーマットを含む二重特異性抗体を合成するための特定の組換え戦略が開発されており、例えば、DVD-Ig (Dual Variable Domain antibodies)、Triomab、two-in-one抗体などの免疫グロブリンG (IgG)ベースのフォーマットとして使用することができます。
同社は上記の最も包括的な二重特異性抗体を高純度および親和性で合成するための多くの高度な戦略 (組換えDNA技術、ファージディスプレイ技術など)を提供しています。
二重特異性抗体の製品リスト
詳細は下記リンク先のメーカーサイトより検索の上、お気軽にお問い合わせください。
- Tandem scFv
Tandem scFvs are a class of bispecific antibody fragments. Two or more moieties of scFv string together to form tandem scFv, which has 1+1 (+1…) antigen-binding valency. - Tandem Fab
Tandem Fab is bispecific and has monovalent specificity for each antigen (1+1 antigen-binding valency). - Diabody
Diabody is a dimer of scFv. Bispecific Diabody has monovalent specificity for each antigen (1+1 antigen-binding valency). - IgG-scFv
IgG-scFv is a type of appended IgGs. It is bispecifc and can be 2+2, 2+1+1, 1+1+1+1 antigen-binding valency. - CrossMab
CrossMab is a type of IgG-like bispecific antibody. Similarly to conventional IgG, CrossMab is bispecific and bivalent molecule, 1+1 antigen-binding valency. - IgG-IgG
IgG-IgG conjugates are formed by chemical linkage. Parental antibodies with special tags can be conjugated in 1:1 to form dimers. - Triple Body
Triple Body (also known as Tribody, not the scFv triple-body) is a multifunctional rAb derivative, combination of Fab with additional entities. - Fab-IgG
Fab-IgG (also tandem Fab-Fc in the construct) is a format of appended IgGs, the IgG scaffold with Fab fragment in the N terminus. They are symmetric bispecific and tetravalent molecules, 2+2 antigen-binding valency. - TandAb
TandAb (Tandem diabody) is a tetravalent bispecific molecule, 2+2 antigen-binding valency, consisting solely of Fv domains. They have been studied as BiTEs or BiKEs in tumor immunotherapy. - Single-chain Diabody
Single-chain Diabody (scDb) is a derivative of Diabody. scDb connects the first chain and the second chain of diabodies by a flexible linker, transforming the heterodimeric format of diabody into a single-chain format. - Single-chain Triplebody
Single-chain triplebody (Sctb) can be regarded as tandem scFv in terms of the structure. It has three tandem scFv units, bispecific or trispecific, 2+1 or 1+1+1 antigen-binding valency. - Fab-Fv
Fab-Fv is a bispecific, bivalent (1+1) fragment. It is generated by a VH domain fusing to the C-terminal of a Fd fragment and a VL domain to a light chain. - Minibody
Minibody is a bispecific, bivalent (1+1) fusion molecules. It is constructed by two scFvs fused to the CH3 domains respectively. The KIH CH3 serves as heterodimerization domain. - Bispecific Immunotoxin
Bispecific immunotoxins (BITs) are hybrid molecules with two specific targeting ligands fused to a toxin moiety. The toxins reach specific diseased tissue guided by the bispecific targeting molecules and perform the cytotoxic effects. - scFv-based Bispecific Fragments
Scfv fragments are a class of units that are commonly used to generate BsAbs. Beside the formats widely studied, there are numerous other scFv-based bispecific fragments. - Bibody
Bibody is a Fab-scFv fusion protein which utilizes Fab as the scaffold and scFv is incorporated to the C-terminus of Fd or light chain. It is a bispecific, bivalent molecule. - Constant Domain-extended Bispecific Fragments
CH3 domains or Fc region can be fused to bispecific fragments to extend their serum half-life. - Appended IgGs
Monospecific IgGs can be engineered by fusing additional antigen-binding units such as scFv, Fab, protein scaffolds, etc. - Fab-scFv Fusion Proteins
Fab and scFv are two main binding units to generate bispecific antibodies. There is a class of BsAbs comprising both Fab and scFv. - Single chain IgGs
Single chain IgGs (scIgGs) have same domain with conventional IgGs. They are bispecific and have 1+1 antigen-binding valency for each antigen.